Acetorphan and diarrhoea.

Effects of acetorphan, an enkephalinase inhibitor, on experimental and acute diarrhoea.

Acetorphan is an orally active inhibitor of enkephalinase (EC 3.4.24.11) with antidiarrhoeal activity in rodents apparently through protection of endogenous enkephalins and a purely antisecretory mechanism. Its antidiarrhoeal activity in man was assessed in an experimental model of cathartic induced secretory diarrhoea as well as in acute diarrhoea of presumed infectious origin. In six healthy ...

Probiotics, antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in humans.

Probiotics are living organisms which, when ingested, have a beneficial therapeutic effect. Examples are bacteria, especially Lactobacillus rhamnosus GG, and the yeast Saccharomyces boulardii. Controlled trials indicate a benefit of both of these in the prevention of antibiotic-associated diarrhoea. Other less effective probiotics are Lactinex, Enterococcus faecium and bifidobacteria. In the di...

Diarrhoea: mechanisms and treatment.

Cryptosporidium and diarrhoea.

Jaundice and infantile diarrhoea.

Although it is recognized that infantile diarrhoea may sometimes be complicated by jaundice, the pathogenesis of this jaundice has not been fully eltucidated. The only detailed account of the hepatic lesions in infantile diarrhoea is that of Wainwright (1950), who described in 11 of his 16 cases a form of 'hepatitis' characterized by periportal parenchymal necrosis, infiltration by polymorphonu...